Showing posts with label avery gilbert. Show all posts
Showing posts with label avery gilbert. Show all posts

Tuesday, April 27, 2010

Does Lily of the Valley Act as a Sex Attractant?

The first molecule to challenge the notion that women smell more efficiently than men is revealed, having the dubious ~but fascinating too~ privilige of being the one which also activates OR1D2; that's the human olfactory receptor which, besides being found in the human nose, is also expressed in human sperm cells! Yes, sperm cells actually "smell" all right! The molecule is the aldehyde Bourgeonal and it smells of lily of the valley, also known and referenced as muguet. (Makes you rethink that green Ajax Fête des fleurs you've been using to mop your floor, doesn't it?)
So, do the little swimmers go straight for the dip into your lily of the valley lathered and scented, ahem, private parts? (Lily of the valley substitutes have been for long used in soap making). But before you go out of your way to also clear the shelves of your closest perfumery hall off their stock of Diorissimo and Envy, take a moment to think and appreciate the facts:

It's Bourgeonal alone which activates testicular odor receptors [Science, 2003] and not another lily of the valley aromachemical and it was one among 100 ingredients screened for receptor activation abilities. Bourgeonal just happened to be one of them, which doesn't exclude that there may be others, even more capable of the job. German scientist Hanns Hatt is nevertheless so convinced that he wrote a book (in German) touching upon it with the title: "The lily of the valley phenomenon: All about smell and how it affects our lives". (There could be hundreds of applications in either fertility or contraception products in the future, I guess, not to mention a distinct stirring of the market off the pheromones and into muguet territory! Think about that for a moment...).
The beginning of the research on sperm odour receptors predates this: "Dr. Parmentier, working with researchers in Holland and France, accidentally discovered the sperm receptors while looking for genes that help control thyroid hormones. Using a technique called polymerase chain reaction to scare out even shadows of gene activity from tissue samples, they stumbled on a family of receptor genes active in male germ cells, the precursor tissue that matures into sperm". [source]

To revert to bourgeonal, according to the snippet which I found at First Nerve, where the news was posted, "Peter Olsson and Matthias Laska at Linkőping University in Sweden have finally found a molecule that men detect at reliably lower concentrations than women. It’s an aromatic aldehyde called bourgeonal and as we shall see it’s an interesting molecule for other reasons. [...] Bourgeonal is a potent molecular signal that is critical to sperm chemotaxis, In other words, it’s what sperm use to find their way to the egg. So it makes more than a little evolutionary sense that bourgeonal detection is ramped up in men and their gametic representatives". Of course, Dr.Avery Gilbert has the right humorous tone of telling the facts, so go over and take a read.
But where does the attracting ingredient come from, biologically speaking? "Is it the egg itself, or some other part of the female reproductive tract? 'It could be that the egg is releasing an attractant that helps guide the sperm to the egg, but the problem is that we don't yet know whether, in fact, the egg is the source of that attractant,' Donner Babcock says". [source]

Searching around the Internez I found a post from Jenny van Veenen in Perfume Making back from August 2007, in which she tackles exactly bourgeonal for it sperm kinetics capabilities. The VERY interesting fact and with an especially related connection to perfumes is that "the aroma chemical 'Undecanal' (Aldehyde C-11 undecylenic, waxy/fatty/rose/citrus odor) appears to block the effect of Bourgeonal and inhibits the chemo sensory response in sperm cells. " So watch out those aldehydes if you're trying to get pregnant, you might check out the products you use or if you're trying to avoid getting pregnant you might embrace undecanal etc. A brave new world indeed.

More reading: NY Times , Health 24 and 3Sat (in German)

pic from Perfume Making

Tuesday, November 10, 2009

Avery Gilbert talks to Katie Puckrik



Very interesting interview: cute, relevant questions, non-technical, accurate replies.

Sunday, October 12, 2008

What the Nose Knows by Avery Gilbert: book review & preview

If you have been even marginally interested in scent and that mysterious and unaccredited source of fascination, repulsion and pleasure, the nose, then you must be in the know about a pleiad of myths, quotes and cognoscible pop-culture references: Proust's madeleine bursting forth 3000 pages of spirally-tapped prose, Zola's candid olfactory descriptions, Freud casting the aspersion of the smell as a lesser sense in advanced civilizations theory, Hellen Keller being the blind and deaf genius of nasofanatics, the sex-attraction of pheromones, sniffing coffee beans between fragrant sampling and the sweet smell of death. I should know, I read this ramification almost every day as they appear by both budding and seasoned smell fanatics on the online fora where osphresiophilia is being discussed among similarly-wired minds.
Avery Gilbert's book "What the Nose Knows" manages to dispel those and countless others in pellucid style, providing solid experimental data and studies to back up every claim; even minutely tracing the published sources of popular myths to exactly nil! (like the ultra-popular "10000 odours is the number of different odors humans can distinguish"). Some of that debunking crescendo is bordering on incredible: it's not easy to accept that we're not that inferior to our dogs' capacity for odor perception (or rats' for that matter) or that said canine's ability to sniff bladder cancer ~and not just any form of cancer as erroneously surmissed~ is not that spontaneous as one might think, taking in mind the rigorous training the subjects required in order to yield those astounding results which made the round of the globe fairly recently.

Dr.Avery Gilbert is a biologist, smell scientist, sensory psychologist and fragrance-industry insider who has worked in the R&D division of several perfume companies (such as Givaudan-Roure) and is now president of Synesthetics, Inc., a provider of innovative sensory science for the development and marketing of consumer products. He has contributed chapters to various edited volumes and published scientific papers in prestigious publications such as Nature.(a selection can be downloaded here) "What the Nose Knows" is his first book. But what prompted him into fruictifying?
"A review of Chandler Burr's The Emperor of Scent set me on the path to my own book: I was the only reviewer to give
"Emperor" a big thumbs down. (I was also the only scientist to
review it; the Washington Post, for example, assigned it to their beauty editor.) My notice appeared in Nature Neuroscience shortly before the AChemS conference, a big annual meeting of smell and taste researchers in Sarasota, Florida. Book reviews rarely attract attention in the scientific world--you're lucky if your mom reads it. Yet colleague after colleague at AChemS came up to congratulate me and say how much
they liked the review. More than a few suggested I should write my own book".
He introduces himself with a sense of humorous acceptance: "I was among the first people to smell Eizabeth Taylor's White Diamonds, but also one of the first to sniff purified 3-methyl-2-hexenoic acid ~the aromatic essence of ripe, unwashed armpits." OK, we can stop being envious of his job at this point, I guess...

Full of interesting trivia and bypassing the cliché Napoleon's odorlagnia-laced billet doux to Joséphine (which every book on smell quotes anyway) Avery Gilbert goes instead for more treacherous waters, such as the flower idolatry of Emily Dickinson, Nathaniel Hawthorn's little-publicized smell vignettes, the verse of Walt Whitman who idolised sweat and Richard Wagner's obsession with scent. Literature and the arts get their own section where the author goes into detail about shattering some of our preconceptions on literary odorphilia. Culinary enthusiasts will be excited over the crossover between food and wine aromas' comparisons and the attenuation of smell principles into a few dozen "flavor principles", as inspired by the work of Liz Rozin, will provide endless discussion. The forensically inclined will derive lots of info on how smell plays a paramount role in recognising stages of corpse decay, the astounding and gruesome realities of "New York deaths" and the not-urban-myths of corpses being hidden to rot under motels' beds; while the perversely intriguing issue of malodor gets its own fair treatment, from the scent of flatulence to the recreation of mamoth feces's aroma which is one of archaeology's dirty secrets (and boy, do I know).

A central point of the book, prompted by the Proustian rush of memories via the infamous soggy French delicacy, is the erosion of olfactory memory: “The purity and infallibility of smell memory ~an insight central to Proust’s literary conceit~ doesn’t hold up to scientific scrutiny.” This might give us pause for thought in our endless discussion about how fragrances change, even in placing faith into the recollections of experts who swear that batches of what they had smelled 40 years ago had a certain je ne sais quoi which is now absent or cannot be replicated. Could it be that it's all a projection of fears and desires like wet dreams and nightmares and our memory bushels the past into a more pleasing set of dimensions?

One of the most interesting chapters of the book is indeed devoted to "Spin Doctors": not con artists, but the scientists who have tried to come up with solid, measurable facts as to how the power of suggestion influences us into thinking something odoriferous is pleasant or unpleasant, potent or weak or even whether it is there at all! Like a perfume enthusiast said a propos of a similar point: "[it's like] the time when fluoride was about to be added to the water supply. Many people were horrified. This would surely kill them all! They displayed corroded pots and pans on the news, claiming that the fluoride had eaten away the metal. Indisputable proof, right? Except...Oops!....the fluoride hadn't been added to the water yet." Reading hard science data gathered via sensory experiments corroborating this somehow leaves you with the realisation that it suffices for some malignant acquaintance to fault your scent with smelling like something considered upleasant (enter any of the usual put-downs: urine, poo, bugspray, mustiness, creosote etc.) to make you believe you suddenly smell it yourself. It doesn't even matter whether the commentator really picks up the designated odour, it's enough that they proclaim it as such for your mind to conjure olfactory images of the offending attributes. This is stretched further to include M.C.S. (multiple chemical sensitivity), on which Gilbert hypothesizes that it might be a purely psychogenic illness despite his sympathy to the afflicted parties: the fear of an odor's power, as attributed by people into odors they consider fabricated, synthetic or otherwise malevolent, has the tangible potential to make them ill, manifesting actual physiological responses, as proven through university experiments and Van der Bergh's work at the University of Leuven, Belgium. And then again many might be attributed to bad associations: the case of former Playboy bunny Izabella St.James' aversion to baby oil or a WWII veteran's memory of crematories alerting him to a nearby funeral home scandal in Hesperia, northeast of Los Angeles, being two.

The reverse is also true, although on a less impressive manner, which accounts for the vividly purple prose we so often encounter through ad copy for fragrance products that promise olfactory utopia. Or even the subtle manipulation of audiences through scent, in cunningly consumerism overtones, such as the scenting of air in shops, as well as in fascinating and pioneering work such as that of Eric Berghammer, alias Odo7, a young Dutch artists touted as the world's first Aroma Jockey. Even the Hollywood use of Smell-o-Vision notoriety ~but not originality, as attested by previous paradigms dating back to the silent film era!~ through John Walters' film Polyester with Divine gets its fair share of analysis, leading to Andy Warhold "smell museum" and the hypothesis of science providing us with our own personal library of scents in the future through the human genome project, where the author is at his element.

Although the tone is light, it is not oversimplified to the point of condescending nor is it ever snarky, yet I would personally be thrilled if the author invited us into his experiences working on fragrant projects for commercial products: the whistleblower touch is always titillating to read. Additionally the attempt at humor sometimes sounds a little strained as if some sort of cathartic relief was needed after some truly gruesome facts presented: I'd like to think that we're able to handle it and if not, what were we doing reading a book on smell (as contrasted to perfume) anyway?

If nothing else, What the Nose Knows will make you never see Marcel Proust with the same eye again and if you have sat through Swann's Way into your literary pilgrimage with the inward impatient questioning "where are those promised odour landscapes?", it will provide welcome vindication. Even more encourangingly, the author proposes that there are no olfactory geniuses and the problem of correctly identifying odours (the "tip of the nose" syndrom) has to do with cognitive diffuculty more than sensory. He proposes that all one needs to be considered as such is an average sense of smell, empathy and a well-developped olfactory imagination. So there's hope for everyone it seems.

The book is published by Crown Publishers, NY and can be ordered through Amazon for $16.29 as part of a promotional offer.
Dr. Avery Gilbert maintains a site and a blog, First Nerve.

Sniffapalooza is featuring Avery Gilbert as one of their speakers at their annual Fall Ball on October 25, 2008, at New York City . He will discuss the psychology of odor perception and the enjoyment of perfume during a luncheon at the restaurant Opia, 130 E. 57th Street. The event begins at 12:30 p.m. Tickets and registration required.


Pic of book jacket through Avery Gilbert, madeleine pic through Les Ateliers du Parfum.

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